The place of cannabis in global drug prohibition is in crisis, opening up new directions for socially engaged cannabis research. The Routledge Handbook of Post-Prohibition Cannabis Research invites readers to explore new landscapes of cannabis research under conditions of legalization with, not after, prohibition: "post-prohibition." The chapters are organized into five multidisciplinary sections: Governance, Public Health, Markets and Society, Ecology and the Environment, and Culture and Social Change. Case studies from the United States, Uruguay, Morocco, and the United Kingdom show readers alternative ways of thinking about human–cannabis relationships that move beyond questions of legality and illegality. Representing a cross-section of cannabis scholarship, the contributors provide readers with critical perspectives on legalization that are not based upon orthodoxies of prohibition. While legalization signals a global shift in the legitimacy of cannabis research, this collection identifies openings for academics, policy makers, and the public interested in ending the drug war, as well as a way to address broader social problems evident in the age of neoliberal governance within which prohibition has been entangled.